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Erotisk Pregnancy-associated plasma protein A - Wikipedia Pictures

PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests Chubcam Down syndrome.

This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins IGFBPs. PAPPA's proteolytic function is activated upon collagen binding.

It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of Submissive Redhead protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses fetuses with an abnormal number of chromosomes.

Pregnancy-associated plasma protein A has been shown to interact with major basic protein. Studies conducted at the Royal London Hospital in the United Kingdom, have shown that a marker of Down's syndrome may be expressed during the first trimester and second trimester of a pregnancy term. This Pappa Body -related article is a stub.

You can Bidy Wikipedia by expanding it. From Wikipedia, the free encyclopedia. Chromosome 9 human [1]. National Center for Biotechnology Information, U. National Library of Medicine. PMID S2CID October The Journal of Biological Chemistry.

Disulfide structure and carbohydrate attachment". July PMC Sinosich MJ, Zakher A Pappa Body and Obstetric Investigation. Bischof P, Tseng L April American Journal of Reproductive Immunology and Microbiology. Clinical Reproduction and Pappa Body. Journal of Reproductive Immunology. Schindler AM, Bischof P Journal of Bone and Mineral Research. June Cytogenetics and Cell Genetics. Evidence for expression in the brain and induction by cAMP".

European Journal of Biochemistry. March Bibcode : PNAS Biology of Reproduction. The Journal of Ppapa Endocrinology and Metabolism. Proteases : metalloendopeptidases EC 3. Categories : Genes on human chromosome 9 Protein stubs.

Hidden categories: All stub articles. Namespaces Article Talk. Views Read Edit View history. Help Papa to edit Community portal Recent changes Upload file.

Download as PDF Printable version. Gene location Human. Gene location Mouse. Chromosome 4 mouse [2]. RNA expression Pappa Body. Chr 9: Chr 4:

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PAPPA is a secreted protease whose main substrate is insulin-like growth factor binding proteins. Pappalysin-1 is also used in screening tests for Down syndrome. This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins IGFBPs.

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